The rates of major malformations after gestational exposure to isotretinoin: a systematic review and meta-analysis > Achievement

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Achievement

국외
Obstet Gynecol Sci.
The rates of major malformations after gestational exposure to isotret…
2021
SCOPUS
Choi, E. J., Kim, N., Kwak, H. S., Han, H. J., Chu

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[The rates of major malformations after gestational exposure to isotretinoin: a systematic review and meta-analysis]

 

Abstract

Objective

Isotretinoin is among the most notorious human teratogens, documented originally as causing up to 30% of malformations. This systematic review and meta-analysis aimed to evaluate the rates of major malformation (MM) among isotretinoin-exposed pregnant women over the years through a systematic review and meta-analysis.


Methods

Eligible studies were searched and identified using various databases. Single-arm meta-analysis and meta-analysis of odd ratios among controlled studies were performed using Review Manager version 5.3.


Results

Ten eligible studies that combined 2,783 isotretinoin-exposed women were included in our study. The rate of MM weighted for the sample size was 15%. Three studies that included an unexposed comparison group were eligible for the meta-analysis. The pooled odds ratio of MM for isotretinoin-exposed women was 3.76. After 2006, the pooled odds ratio of MM for isotretinoin exposure was significantly lower at 1.04.


Conclusion

The current rate of MM in isotretinoin-exposed women was substantially lower after 2006.

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